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Food Additives & Contaminants: Part A Volume 34, 2017 - Issue 1
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Original Articles

Validation of a method for sedatives and β-blockers determination in swine, bovine and equine kidney using liquid chromatography coupled with tandem mass spectrometry

Lenise Guimarães de OliveiraEscola de Química e Alimentos, Universidade Federal do Rio Grande - FURG, Rua Barão do Caí, 125 Santo Antônio da Patrulha, BrazilCorrespondence[email protected]
View further author information
,
Fabiano BarretoLaboratório Nacional Agropecuário – LANAGRO/RS, Ministério da Agricultura, Pecuária e Abastecimento, Porto Alegre, BrazilView further author information
,
Rodrigo HoffLaboratório Nacional Agropecuário – LANAGRO/RS, Ministério da Agricultura, Pecuária e Abastecimento, Porto Alegre, BrazilView further author information
,
Gabriel RübensamLaboratório Nacional Agropecuário – LANAGRO/RS, Ministério da Agricultura, Pecuária e Abastecimento, Porto Alegre, BrazilView further author information
,
Marcia Helena Scherer KurzEscola de Química e Alimentos, Universidade Federal do Rio Grande - FURG, Rua Barão do Caí, 125 Santo Antônio da Patrulha, BrazilView further author information
,
Gabriela GalleEscola de Química e Alimentos, Universidade Federal do Rio Grande - FURG, Rua Barão do Caí, 125 Santo Antônio da Patrulha, BrazilView further author information
&
Fábio Ferreira GonçalvesEscola de Química e Alimentos, Universidade Federal do Rio Grande - FURG, Rua Barão do Caí, 125 Santo Antônio da Patrulha, BrazilView further author information
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Pages 32-39 | Received 25 Aug 2016, Accepted 17 Oct 2016, Published online: 21 Nov 2016
 
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ABSTRACT

A method for the determination of five sedatives and 14 β-blocker residues in swine, bovine and equine kidney was validated. Samples were extracted with acetonitrile and purified using dispersive solid phase extraction (d-SPE) with Celite 545 with subsequent analysis by LC-MS/MS. A simplified protocol was applied to validate the method scope extension to include new matrices. Parameters such as recovery, trueness, linearity (r2), relative standard deviation (RSD), decision limit (CCα) and method capability (CCβ) were measured for the bovine and equine kidney matrices. The method was applied to the analysis of more than 300 real samples and is currently included in the Brazilian National Residue Control Plan.

GRAPHICAL ABSTRACT

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

The present work was funded by FURG and LANAGRO/RS.

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