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Articles

Isolation and structural identification of a novel minoxidil analogue in an illegal dietary supplement: triaminodil

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Pages 2-9 | Received 23 Aug 2017, Accepted 12 Oct 2017, Published online: 07 Nov 2017
 

ABSTRACT

A new minoxidil analogue was detected in an illegal dietary supplement advertised as a hair-growth treatment. The analogue was identified using ultra-performance liquid chromatography (UPLC), high-resolution mass spectrometry (LC-HR-MS) and nuclear magnetic resonance (NMR) spectroscopy. The compound was structurally elucidated as a minoxidil analogue in which the piperidinyl group of minoxidil was replaced with a pyrrolidinyl group corresponding to a molecular formula of C8H13N5O. The new analogue has been named triaminodil. As this is the first report of the compound, there are no chemical, toxicology or pharmacological data available.

Graphical Abstract

Acknowledgments

This research was supported by Research Grants (15181MFDS521 & MFDSAAT2017) from the Ministry of Food and Drug Safety (MFDS) in Korea. This work was supported by the Ministry of Food and Drug Safety and Kangwon National University. The authors thank the Central Laboratory of Kangwon National University for providing them with technical assistance for the spectroscopic experiments.

Disclosure statement

No potential conflict of interest was reported by the authors.

Additional information

Funding

This work was supported by the Ministry of Food and Drug Safety [15181MFDS521 & MFDSAAT2017].

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