Perceived neighborhood social cohesion and cardiometabolic risk: a gene × environment study

ABSTRACT

People living in socially cohesive neighborhoods generally have better health. We extend this research by evaluating the hypothesis that perceived neighborhood cohesion may influence health by attenuating genetic liability for cardiometabolic risk factors. Using data from the Health and Retirement Study (n = 6615; mean age 69.7), we conducted a gene × environment interaction study hypothesizing that perceived neighborhood cohesion would attenuate the link between polygenic scores for waist-to-hip ratio (WHR) and body mass index and a measure of multisystem cardiometabolic risk (systolic and diastolic blood pressure, heart rate, A1c, C-reactive protein, and total and high-density lipoprotein cholesterol). In support of the hypothesis, results indicated that among people perceiving low neighborhood cohesion, higher WHR polygenic scores were associated with greater cardiometabolic risk. In contrast, the genetic-cardiometabolic risk link was much attenuated among those living in neighborhoods perceived as socially cohesive. Our results support community-level interventions to enhance the social cohesiveness of individuals’ neighborhoods which may provide health benefits by reducing the risks associated with known genetic risk factors.

Conflicts of interest

In accordance with Taylor & Francis policy and my ethical obligation as a researcher, I am reporting that none of the authors have any conflicts of interests to report.

Additional information

Funding

This work was supported by the National Institutes of Health/ National Institute on Aging under grants [T32-AG000037-37, 1K99AG055699-01, and R25 AG053227].