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Pathogens and Global Health Volume 111, 2017 - Issue 7
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Prophylaxis of human toxoplasmosis: a systematic review

Senaka RajapakseUniversity Medical Unit, National Hospital Colombo, Colombo, Sri Lanka;Faculty of Medicine, Department of Clinical Medicine, University of Colombo, Colombo, Sri LankaCorrespondence[email protected]
[email protected]
ORCID Iconhttp://orcid.org/0000-0003-1965-6678
ORCID Icon,
Praveen WeeratungaUniversity Medical Unit, National Hospital Colombo, Colombo, Sri Lanka;Faculty of Medicine, Department of Clinical Medicine, University of Colombo, Colombo, Sri LankaORCID Iconhttp://orcid.org/0000-0003-2306-0885
ORCID Icon,
Chaturaka RodrigoFaculty of Medicine, Department of Clinical Medicine, University of Colombo, Colombo, Sri Lanka;Department of Pathology, School of Medical Sciences, University of New South Wales, Sydney, AustraliaORCID Iconhttp://orcid.org/0000-0003-2189-9177
ORCID Icon,
Nipun Lakshitha de SilvaUniversity Medical Unit, National Hospital Colombo, Colombo, Sri Lanka;Faculty of Medicine, Department of Medicine, General Sir John Kotelawala Defence University, Rathmalana, Sri LankaORCID Iconhttp://orcid.org/0000-0002-4467-3659
ORCID Icon &
Sumadhya Deepika FernandoFaculty of Medicine, Department of Parasitology, University of Colombo, Colombo, Sri LankaORCID Iconhttp://orcid.org/0000-0002-2535-9031
ORCID Icon
Pages 333-342 | Published online: 26 Sep 2017
 
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Abstract

Toxoplasmosis is an infection caused by the intracellular protozoan parasite Toxoplasma gondii, and is associated with clinically significant infection in immunocompromised individuals. Vertical transmission during pregnancy can manifest as congenital toxoplasmosis in the neonate, and can have serious consequences. This review aims to describe the modalities for prophylaxis of toxoplasmosis in susceptible populations, and focuses on the following: (1) prophylaxis of congenital toxoplasmosis; (2) prophylaxis of toxoplasmosis in patients with HIV/AIDS; and (3) prophylaxis of toxoplasmosis in transplant recipients.

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