Abstract
Recently, mutations in genes related to frontotemporal dementia and/or amyotrophic lateral sclerosis have been described as the cause of late onset psychosis. Here, we report a 68-year-old patient, carrier of a mutation in the gene encoding ubiquilin-2 (UBQLN2), who presented adult onset psychotic manifestations followed by a dysexecutive syndrome compatible with the diagnosis of behavioral variant of frontotemporal dementia. Therefore, we suggest that variants in UBQLN2 should be sought in patients with this clinical condition preceded by psychiatric disorders.
Ethical approval
The study was approved by the local Ethics Committee and informed consent according to the Declaration of Helsinki was obtained by both the patient and her family caregiver.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.