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Brief Reports: Genomics

Analysis of STMN2 CA repeats in italian ALS patients shows no association

, , , , , , , , , & show all
Pages 152-154 | Received 23 Apr 2022, Accepted 04 Jul 2022, Published online: 23 Jul 2022
 

Abstract

Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease caused by a complex interaction of genetic and environmental factors. Recently, a polymorphic intronic CA repeat in STMN2 gene has been proposed as risk factor for ALS. The presence of long/long CA genotype, especially if one allele had 24 CA, was reported to be significantly associated with the disease in a cohort of sporadic ALS patients. We tested an Italian cohort of 366 ALS patients and 353 healthy controls and we found no association between CA length and ALS risk.

Keywords:

Acknowledgements

The authors are grateful to patients involved in our study. The authors thank ICOMM Onlus for supporting our research. P.N.D. is supported by a postdoctoral fellowship from ICOMM Onlus.

Declaration of interest

No potential conflict of interest was reported by the author(s).

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