Junctional proteins of the blood-brain barrier: New insights into function and dysfunction

abstract

The blood-brain barrier (BBB) is a highly complex and dynamic barrier. It is formed by an interdependent network of brain capillary endothelial cells, endowed with barrier properties, and perivascular cells (astrocytes and pericytes) responsible for inducing and maintaining those properties. One of the primary properties of the BBB is a strict regulation of paracellular permeability due to the presence of junctional complexes (tight, adherens and gap junctions) between the endothelial cells. Alterations in junction assembly and function significantly affect BBB properties, particularly barrier permeability. However, such alterations are also involved in remodeling the brain endothelial cell surface and regulating brain endothelial cell phenotype. This review summarizes the characteristics of brain endothelial tight, adherens and gap junctions and highlights structural and functional alterations in junctional proteins that may contribute to BBB dysfunction.

Keywords:

• actin cytoskeleton
• adherens junction
• brain endothelial cells
• cell-cell contact
• gap junction
• tight junction

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Funding

This work was supported by Public Health Service grant NS075757, NS062853 from the National Institute of Neurological Disorders (A.V.A) and 1-16-IBS-008 from American Diabetes Association (A.V.A).