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Abstract
Irbesartan is an anti-hypertensive drug administered orally. To attain controlled release and to reduce side effects due to dose dumping, Irbesartan is formulated as hydrogel microbeads by using natural polymers like Sodium alginate and Chitosan through ionotropic-gelation method. The prepared hydrogel microbeads were evaluated for drug entrapment efficiency (% DEE), cumulative drug release (% CDR) and swelling index (% SI). The % DEE of all the formulations were within the range of 65.02 - 90.08% with in-vitro drug release of 84.02 - 98.64% over 12 h. The drug release was found to be in a controlled manner following zero order kinetics. Based on % DEE, % CDR and swelling index values, formulation F9 was optimized. The optimized hydrogel microbeads were evaluated for surface morphology using SEM, XRD and compatibility studies using FTIR. SEM results showed that the formed microbeads are spherical, uniform and porous. XRD patterns proved that the drug in the formulation got transformed to amorphous form. No interaction between the drug and excipients was observed from FTIR studies.