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Abstract
Five simple, accurate, selective and sensitive UV spectrophotometric methods have been developed and validated for the determination of cefadroxil monohydrate in the presence of its alkali-induced degradation product without preliminary separation. These methods include ratio subtraction, absorbance subtraction, amplitude modulation, dual wavelength and simultaneous equation method. These methods were validated and successfully applied for determination of cefadroxil monohydrate in Duricef® capsules. The obtained results were statistically compared with those of the reported method by applying t-test and F-test at 95 % confidence level and no significant difference was observed regarding accuracy and precision.