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Abstract
Voltammetric resolution of neurotransmitter epinephrine (EP) in presence if uric acid (UA) was achieved at niacin film coated carbon paste electrode (niacin/CPE) in 0.2 M PBS of pH 7.4 by cyclic voltammetry (CV) technique. The fabricated electrode remarkably enhanced an electrocatalytic activity towards the oxidation of epinephrine, resulting in the irreversible general 2-electrontransfer adsorption controlled phenomenon. The effect of several experimental parameters were discussed. Such as, scan rate, pH and concentration. Under optimal conditions, the anodic peak current (Ipa) was proportional to epinephrine concentration over the range 20.66-174.4 μM, (r2=0.9976) with a detection limit of 11.3 nM by CV technique. The sensitive, selective and reproducible result obtained at the niacin/CPE. Finally, the developed method was successfully applied for determination of epinephrine in pharmaceutical samples.