Analgesic and Anti-inflammatory Activities of Boswellia elongata balf Methanolic Extracts, as Endemic Plants in Yemen

Abstract

We evaluate the analgesic and anti-inflammatory activities of leaves of Boswellia elongata balf methanolic extract an experimentally induced acute inflammation in rats. This study was carried out by using male and female Swiss mice (20–30 g) and Wister male rats (180–220 g). The methanolic extracts were prepared by using maceration at room temperature (25°C) over period 48 h. The effects of methanolic extracts of B. elongata balf was investigated for anti-inflammatory properties by using carrageenan and experimental trauma-induced hind paw oedema in rats. The analgesic activities were performed by using chemical and thermal models which will induce acute pain in animal models. The anti-inflammatory properties oral administration of extract at the dose of (50, 100 mg/kg p.o., respectively) showed significant reduction (P≤0.001) and inhibition of oedema induced by carrageenan and experimental trauma in hind paw of rats when compared with control and standard drug (Indomethacin). We can conclude that, B. elongate balf methanolic extract have not central analgesic effect and have peripheral analgesic as anti-inflammatory activities, supporting the traditional application of this plant in treating various diseases associated with inflammation and pain.

Key words:

• Medicinal plants
• Boswellia elongate balf
• Methanolic extracts
• Anti-inflammatory activity
• Analgesic activity