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Abstract
Desmostachya bipinnata, Gramineae (Poaceae) family, has been traditionally used in treatment of various disorders like asthma, kidney stone, diarrhoea, wound healing etc. Several extracts of Desmostachya bipinnata were prepared. Ex-vivo estimation of contractile responses of guinea pig ileum were measured for prepared extracts against histamine and compared with chlorphenirame. All the extracts were able to contract guinea pig ileum while alcoholic extract was superior among all. Such results indicated that prepared extract possess good anti-histaminic activity, which was further confirmed with histamine induced lethality test. Histamine induced lethality in guinea pigs was prevented when the extracts were administered prior to histamine injection in guinea pigs. Hence, it is concluded that the extracts possess anti-histaminic activity and may possess anti-asthmatic potential.