Disrupted resting-state functional connectivity of frontal network in opium use disorder

Abstract

Opioid use disorder (OUD) as a chronic relapsing disorder is initially driven by dysfunction of brain reward networks and associated with several psychiatric disorders. Resting-state EEG was recorded in 24 healthy participants as well as 31 patients with OUD. Healthy participants do not meet OUD criteria. After pre-processing of the raw EEG, functional connectivity in the frontal network using eLORETA and all networks using graph analysis method were calculated. Patients with OUD had higher electrical neuronal activity compared to healthy participants in higher frequency bands. The statistical analysis revealed that patients with OUD had significantly decreased phase synchronization in β1 and β2 frequency bands compared with the healthy group in the frontal network. Regarding global network topology, we found a significant decrease in the characteristic path length and an increase in global efficiency, clustering coefficient, and transitivity in patients compared with the healthy group. These changes indicated that local specialization and global integration of the brain were disrupted in OUD and it suggests a tendency toward random network configuration of functional brain networks in patients with OUD. Disturbances in EEG-based brain network indices might reflect an altered cortical functional network in OUD. These findings might provide useful biomarkers to understand cortical brain pathology in opium use disorder.

Keywords:

• Electroencephalogram
• eLORETA
• functional connectivity
• graph analysis
• opium use disorder

Acknowledgments

The authors would like to thank Zanjan University of Medical Sciences for supporting this research. There is no funding to declare.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Data availability statement

The dataset generated and analyzed during the current study is available from the corresponding author on reasonable request.