Novel variants of mitochondrial DNA associated with Type 2 diabetes mellitus in Moroccan population

Abstract

In this study, we investigated the association of mtDNA variants and haplogroups with Type 2 diabetes (T2D) in Moroccan patients. The Hypervariable Segments 1 of the mtDNA was sequenced in 108 diabetic patients and 97 controls. Association analyses were performed using Fisher’s exact test and multivariate logistic regression. The prevalence of five mtDNA variants (C16187T, C16270T, T16172C, A16293G, and C16320T) was significantly higher in cases than in controls. Among these variants, only C16270T (p = .02) and C16320T (p = .03) remains significant after adjusting by age and gender. We showed that C16270T and C16320T variants were strongly associated with increased risk of T2D in Moroccan patients.

Keywords:

• Mitochondria
• hypervariable segment 1
• mitochondrial variant
• genetic association
• Type 2 diabetes

Acknowledgments

The authors would like to thank all patients and their families for their collaboration.

Disclosure statement

The authors declare no conflict of interest.