Plant mediated green synthesis and nanoencapsulation of MgO nanoparticle from Calotropis gigantea: Characterisation and kinetic release studies

Abstract

This paper aims to report a sustainable novel green synthesis of MgO nanoparticles using leaves extracts of Calotropis gigantea. The average size of MgO nanoparticles obtained was 48.38 nm with the crystallite size of 8 nm. MgO nanoparticles were encapsulated by employing emulsion solvent evaporation. Nanoencapsulation of MgO nanoparticles using Eudragit L was found to produce particle size of 53.37 nm at higher stability. It was also observed that Eudragit L-Mgo nanoparticles had higher entrapment efficiency, drug loading and yield. Lastly, the drug release of Eudragit L-MgO nanoparticles was found to follow Fickian diffusion mechanism and fitted well with Weibull model.

KEYWORDS:

• Diabetes mellitus
• MgO nanoparticles
• Calotropis gigantea
• nanoencapsulation
• kinetic study

Additional information

Funding

This work was supported by Curtin University Malaysia.