Abstract
From the reaction of 1,2-diaminobenzene 1 with cephalexin 2 antibiotic a cephalexin–based Schiff base (HL) 3, was obtained and the transition metal Schiff base complexes were synthesized. The products were characterized by physical and spectral techniques, namely, UV–Vis, FT-IR, 1H-NMR, EPR, MALDI mass spectrometry, magnetic susceptibility, molar conductance, molecular modeling, together with elemental and thermal analysis. The general composition [M(L)(OAc)(H2O)2], M(II) = Mn2+ 4, Co2+ 5, Ni2+ 6, Cu2+ 7, Zn2+ 8, where L represents deprotonated tridentate NNO Schiff base, have been assigned to the adducts. Direct calcinations of the complexes 6 and 8 at 700 °C resulted high-quality metal oxide (MO) nanoparticles. Paper disc diffusion method was used to test the bactericidal activity of the synthesized products.
Acknowledgements
The authors thanks to the Universidad de Oriente (UDO) and Universidad de Playa Ancha (UPLA) for continuous support.