Synthesis, crystal structure and anticancer activity of the dibutyltin(IV)oxide complexes containing substituted salicylaldehyde-o-aminophenol Schiff base with appended donor functionality

Abstract

Schiff base butyltin complexes C1 ∼ C3 have been synthesized via the reaction of dibutyltin oxide with the substituted salicylaldehyde-o-aminophenol Schiff base ligands (L1 ∼ L3), respectively. The complexes have been characterized by elemental analysis, IR, UV-Vis, ¹H NMR, 13C NMR spectra and the crystal structures have been determined by X-ray diffraction. The anticancer activity of the Schiff base ligands L1 ∼ L3 and complexes C1 ∼ C3 against five species of cancer cells which are MCF7, Colo205, NCI-H460, Hela and HepG2 were tested respectively, the tests showed that C3 exhibited significant anticancer activity for the cancer cells in comparison with other complexes. The interaction between C3 and calf thymus DNA were studied by fluorescence, UV-Vis and Viscosity experiment, the results show that the interaction of C3 with calf thymus DNA was intercalation.

Keywords:

• organotin
• Schiff base
• synthesis
• crystal structure
• anticancer activity

Additional information

Funding

This work was supported by the Hunan Provincial Natural Science Foundation of China (Nos. 2017JJ3003, 2016JJ5004) and Foundation of Key Laboratory of Functional Metal-Organic Compounds of Hunan Province (No. MO18K01).