Oxidation of procainamide by diperiodatocuprate(III) complex in aqueous alkaline medium: a comparative kinetic study

Abstract

A comparative study of uncatalysed and ruthenium(III) catalyzed oxidation of procainamide(PAH) was carried out spectrophotometrically using diperiodatocuprate(III) in aqueous alkali. Stoichiometry observed was 1:2 (PAH: DPC). The reaction was of first order in both catalyzed and uncatalyzed cases, with respect to [DPC] & [Ru(III)], less than unit order in [PAH] and [alkali]. Negative fraction in [periodate]. Other kinetic parameters viz., ionic strength, dielectric constant, temperature effect and intervention of free radical were also studied. The main oxidation products were characterized by different techniques. The activation parameters with respect to slow step of the mechanism, also the thermodynamic quantities were determined.

Keywords:

• Diperiodatocuprate(III)
• oxidation
• procainamide
• ruthenium(III) catalyst
• thermodynamic parameters

Acknowledgments

One of the author Manjunath D. Meti expresses gratitude to Department of Science & Technology (DST) New Delhi for providing Innovation in Science Pursuit for Inspired Research (INSPIRE) fellowship (IF110548).