Synthesis, characterization of platinum(II) complexes of Schiff base ligands and evaluation of cytotoxic activity of platinum nanoparticles

Abstract

New cytotoxic mononuclear Pt(II) coordination complexes of ligands {hydrazinecarboxamide (L¹H) and hydrazinecarbothioamide (L²H) of 2-hydroxy-1-naphthaldehyde} have been synthesized. Free ligands, their metal complexes, and metal nanoparticles have been characterized based on elemental analysis, melting point, and molecular weight determinations, magnetic measurements, SEM, IR, ¹H NMR, and UV–Visible spectra. Square planar geometry has been proposed to the complexes. The ligands and their complexes exhibit antimicrobial effects against various strains of bacteria and fungi. Platinum(II) nanoparticles were prepared by using green technique. The gel electrophoresis clearly exhibits that the metal complexes along with the ligands show cleavage activity on DNA of Escherichia coli (ATCC 25922). The newly synthesized complexes manifested significant in vitro cytotoxicity against human MCF-7 breast adenocarcinoma cancer cell line with cell death mainly caused by apoptosis. Further, nanoparticles of Pt complex exhibited MCF-7 cell multiplication through induction of apoptotic cell death.

Graphical Abstract

Keywords:

• Antimicrobial effects
• apoptosis
• cytotoxicity
• DNA cleavage
• platinum(II) nanoparticles

Acknowledgments

The authors are thankful to Dr. P. Shivakrishna, Director, Synteny Lifesciences Pvt, Hyderabad, for performing the anticancer and apoptosis activities of the samples. The authors are also thankful to Dr. B Lal Institute of Biotechnology, Jaipur for performing the antimicrobial and DNA cleavage activities.

Additional information

Funding

The authors, Bhavna Gupta and Anita Kumari are thankful to UGC, New Delhi, for financial assistance.