Hepatoprotectant potential of sodium alginate coated catechin nanoparticles (SACC-NPs) in rat model

Abstract

Hepatoprotective effects of many antioxidants have been attributed with its uncertain bioavailability at the target cell. Research in drug delivery today is to design a nano-carrier system to deliver drugs at target cell with desired dose and duration. In this study, sodium alginate coated catechin nanoparticle (SACC-NP) carrier system was evaluated for its in vivo anti-oxidant potential in rat model revealed improvement in hematological, biochemical parameters and oxidative stress markers on day 28^th of SACC-NPs treated group of rats (Gr. V). Significant improvement in healing pattern of liver along with regenerative changes during histopathology studies was observed in the rats of Gr. V. Results of gross pathology and histopathology with the liver of rats receiving SACC-NPs has been re-confirmed again by May-Grunwald Giemsa staining which recorded prominent regenerative changes in liver. Modified scoring pattern also re-ascertained regenerative changes in the liver tissue of the rats receiving SACC-NPs.

Keywords:

• Liver
• Anti-oxidant
• Sodium alginate
• Catechin
• Nano drug delivery

Acknowledgement

The authors are thankful to Indian Council of Agricultural Research, Ministry of Agriculture and farmer welfare, New Delhi, India for providing financial support.