One pot synthesis of bis (dihydropyrimidinone) and tetrahydro-4H-chromenes derivatives using Ag₂O/GO/TiO₂ composite nanostructure

Abstract

In this study, a simple and efficient synthesis reaction was used to prepare Bis (dihydropyrimidinone) derivatives through Biginelli condensation reaction of terephthalic aldehyde, 1,3-dicarbonyl compounds and (thio) urea or guanidine and tetrahydro-4H-chromenes via one pot condensation of aromatic aldehydes, malononitrile, and dimedone with Ag₂O/GO/TiO₂ composite nanostructures as the catalyst. The structural functionalities and morphological observations of catalyst were obtained using characterization techniques of field emission scanning electron microscopy, X-ray diffraction, Fourier transfer infrared (FT-IR) spectroscopy and transmission electron microscope. The structures of Bis (dihydropyrimidinone) and tetrahydro-4H-chromenes were confirmed by FT-IR, NMR, and mass spectroscopy. Excellent yields of products, simple reaction process and simple work-up are attractive features of these effective synthesis methods.

Keywords:

• Ag₂O/GO/TiO₂
• heterogeneous catalyst
• nano composite
• Bis (dihydropyrimidinone)
• tetrahydro-4H-chromenes

Acknowledgment

The current study was partially supported by the Islamic Azad University Ahvaz Branch. The authors would like to thank the Research Council for their generous support of this work.

Disclosure statement

There is no conflict of interest statement enclosed.