Synthesis, characterization, X-ray crystal structures and antibacterial properties of cobaloximes with aniline based ligands containing acid functionality

Abstract

Cobaloximes of the type [Co(X)(dmgH)₂B], where dmgH = Dimethylglyoxime monoanion, X = Cl⁻, Br⁻, SCN⁻ and B = 4-Aminophenylacetic acid (4-APAA) and4-Aminobenzoic acid (4-ABA), have been synthesized. Better yield was obtained when bromide ion was used as an axial ligand. The synthesized cobaloximes were characterized by IR, UV spectroscopy and cyclic voltammetry. The structures of the two cobaloximes [Co(Cl)(dmgH)₂(4-ABA)] and [Co(Br)(dmgH)₂(4-ABA)] have been characterized by X-ray Crystallography. The complexes were screened for their antibacterial activity against gram positive Methicillin Resistant Staphylococcus aureus (MRSA) MTCC 1430 and gram negative Acinetobacter baumannii MTCC 1425 bacteria using Agar well diffusion method, Tube method and Biofilm eradication on biomaterial methods. It has been found that all the cobaloxime complexes exhibited inhibition against both the test microorganisms. Cobaloximes have been found to be more active against the gram negative bacteria compared to gram positive bacteria.

Keywords:

• Cobaloximes
• Functionalized aniline
• Crystal structure
• Structure-activity relationship
• Antibacterial studies
• Biofilm eradication

Acknowledgments

Dr. VV thank the Department of Science and Technology [EMR/2016/006365], INDIA, for the financial support

Conflict of interests

The authors declare that they have no conflict of interests.

Supplementary material

CCDC 1940833 and 1971299 contain the crystallographic data for the complexes. These data can be obtained free of charge via www.ccdc.cam.ac.uk/content/retrieving.html.

Correction Statement

This article has been republished with minor changes. These changes do not impact the academic content of the article.