Structural effects of nanoparticles on their antibacterial activity against multi-drug resistance

Abstract

Despite the availability of various promising antibiotics, bacterial infections still impose a prominent issue of morbidity and mortality. Due to changing environment and widespread misuse of antibiotics, multiple drug- resistance (MDR) strains of bacteria evolved rapidly, intensifying the threat to humankind and environment. Excessive use and diminished potency of current antibiotics against these strains led the foundation; for development of new drug delivery and targeting approaches. Metallic nanoparticles (NPs) provide novel platform to fight against MDR strains. These nano beacons have an intrinsic antibacterial activity or may act as an innovative tool for transporting multiple drugs with augmented biocompatibility. Antibacterial efficiency may be enhanced; by modifying or conjugating surface topology. Intensified NP structure shows effective potency than unmodified ones. This review encompasses how antibacterial activity of NPs offers a novel approach in reducing threats due to MDR bacteria and how their structural changes can affect its antimicrobial activity against MDR.

Keywords:

• Nanoparticles
• multi-drug resistance
• ESKAPE
• dopants
• nanocomposites

Disclosure statement

The authors report no potential conflict of interest.