Biologically active mixed ligand complexes of Co(II), Ni(II), Cu(II) and Zn(II) as potential antimalarial, antidibetic and anticancer agents

Abstract

Mixed ligand complexes of transition metal ions Co(II), Ni(II), Cu(II) and Zn(II) were synthesized using bidentate Schiff’s base (E)-2-((benzo[d]thiazol-2-yliminomethyl)-6-methoxyphenol (L1), derived from condensation reaction of 2-aminobenzothiazole and 2-hydroxy-3-methoxybenzaldehyde, and 5-Chloro-8-hydroxyquinoline (5CHQ) (L2) as ligands. All the synthesized compounds were characterized using elemental analysis, IR, electronic, ¹H and ¹³C NMR spectra, TGA-DTA and Powder XRD analysis, molar conductivity and magnetic susceptibility measurements. Based on the results obtained all the synthesized complexes are proposed to have tetrahedral geometry. All the synthesized compounds were screened for their antioxidant, antimicrobial, antimalarial, antidibetic, anticancer activities and cytotoxicity study using MTT assay. The complexes are proposed to have potential antimalarial, antidibetic and anticancer activities.

Graphical Abstract

Keywords:

• Schiff base mixed complexes
• anticancer
• antidibetic
• antimalarial
• antioxidant

Disclosure statement

All authors declare no conflict of interest including financial, personal or other relationships with other people or organizations for this article.