Sonochemical synthesis of l,4-dihydropyrimidinones catalyzed by reduced graphene oxide encapsulated zinc oxide nanoparticles

Abstract

A simple and efficient one-pot procedure for the synthesis of 1,4-dihydropyrimidinones in ethanol under ultrasound irradiation is described. These heterocyclic compounds were prepared through condensation of aromatic aldehyde, ethyl acetoacetate, urea, or thiourea in the presence of ZnO NPs@rGO nanocomposite as a convenient and reactive catalyst. This protocol has very advantages such as low loading catalyst, excellent product yields, and short reaction times. The structures and morphology properties of ZnO NPs@rGO nanocomposite was investigated by FTIR, XRD, FE-SEM. and EDX techniques. Furthermore, the organic products were identified by melting points, FTIR, and ¹H NMR analyses.

Keywords:

• Dihydropyrimidinone
• aromatic aldehyde
• ZnO NPs@rGO
• nanocomposite
• ultrasound irradiation

Disclosure statement

This paper's authors declare that they do not have any competing financial interests or personal relationships to influence their work.

Additional information

Funding

The authors are grateful to University of Kashan for supporting this work by Grant No. 159148/88.