Budd-Chiari syndrome, large regenerative nodules and hepatocellular carcinoma in antiphospholipid syndrome associated with juvenile systemic lupus erythematosus

Abstract

Hepatic involvement in systemic lupus erythematosus (SLE) may be due to the disease itself, but is most often associated with the use of hepatotoxic drugs, hepatic steatosis and coexistence of viral hepatitis. Cases of Budd-Chiari syndrome (BCS) associated with antiphospholipid syndrome (APS) have been reported in adults with lupus. The authors report a rare case of juvenile systemic lupus erythematosus (jSLE) associated with APS who presented BCS and subsequent progression to large regenerative nodules and hepatocellular carcinoma.

Keywords:

• Antiphospholipid syndrome
• systemic lupus erythematosus
• Budd-Chiari syndrome
• liver neoplasms
• hepatocellular carcinoma

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Informed consent for publication was signed by the patient.

Acknowledgements

All the authors critically revised and approved the final version of the manuscript.

Conflict of interest

None.