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Modern Rheumatology Case Reports Volume 5, 2021 - Issue 2
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Case Reports

IgG4-related disease presenting as a paraneoplastic syndrome: report of two cases and literature review

Mitsuteru Akahoshia Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, JapanCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-3556-4709
ORCID Icon,
Yojiro Arinobua Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Yusuke Kashiwadoa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Aya Omotoa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Masahiro Ayanoa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Hiroki Mitomaa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Yasutaka Kimotob Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Oita, Japan
,
Nobuyuki Onoa Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
,
Takahiko Horiuchib Department of Internal Medicine, Kyushu University Beppu Hospital, Beppu, Oita, Japan
&
Hiroaki Niiroc Department of Medical Education, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
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Pages 371-376 | Received 14 Jan 2021, Accepted 05 Feb 2021, Published online: 15 Mar 2021
 
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Abstract

An association between immunoglobulin G4-related disease (IgG4-RD) and malignancy has been suggested. We report two cases of IgG4-RD with suspected paraneoplastic syndrome. In both patients, malignancy was observed immediately after diagnosis of IgG4-RD, and surgical resection resulted in spontaneous regression of IgG4-RD. We review the reports on IgG4-RD associated with malignancy, including these two cases, and discuss their relevance.

Patient consent

Written informed consent for publication was obtained from both patients.

Ethical approval

Not applicable.

Conflict of interest

None.

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