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ABSTRACT
The collagen hydrolysate (HC) and silver nanoparticles (AgNPs) effect on the mechanical, thermal, in vitro degradation, cytotoxicity and antifungal properties of polylactic acid (PLA) plasticized and compatibilized with a mixture of polyethylene glycol (PEG 4000) and Lapol 108 (MB) was studied. The presence of HC led to the decreased tensile properties and to the increased hydrophilicity of biocomposites surfaces. Tested biocomposites led to a very good cellular viability percentage, unaltered cell morphology and a modest antifungal activity. The extrusion trial showed that the PLA/MB/PEG/AgNPs bionanocomposite is a promising potential material for urinary drains.
GRAPHICAL ABSTRACT
Acknowledgments
This work was supported by a grant of the Romanian National Authority for Scientific Research, CNDI-UEFISCDI, project number 164/2012.
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Funding
Notes on contributors
Maria Rapa
Maria Rapa is currently scientific researcher at Faculty of Material Science and Engineering fromUniversity Politehnica of Bucharest, Romania. Her research focuses on polymeric blends having biodegradability and biocompatibility properties, bio-resources, by-products, environmental protection, developing of nanostructured materials with 3D architecture, characterization of polymers, study of modifications, degradation and their stabilization and evaluation of the thermoplastic polymers’s processability. Dr. Maria Râpă written 52 ISI papers, 3 book chapters, 8 BDI papers, 2 Romanian patents, 1 International patent, has 65 participations at national and international scientific symposiums and conferences, and participated in over 25 applicative research projects.
Raluca Nicoleta Darie-Nita
Raluca Nicoleta Darie-Nita currently works at the Laboratory of Physical Chemistry of Polymers, Petru Poni Institute of Macromolecular Chemistry, Iasi. She 16 years experience in reactive processing of polymer blends (both natural and synthetic), compatibilization and chemical functionalization of polymers as well as physical-chemical characterization of polymer materials (structural, mechanical, morphological, rheology, thermal). Also she published 56 ISI papers, 1 book, 6 chapters, had project director for 2 national grants and participated as member of the team for 15 national and 9 international projects.
Petruta Preda
Dr. Petruta Preda is currently scientific researcher at the National Institute for Research and Development in Microtechnologies, Bucharest, Romania. She has expertise on the methods of sterilization, culture media preparation and conservation, antibiotic sensitivity testing of microorganisms: classical methods (disc method diffusion and microdilution method in liquid medium), flow cytometry, determination of antimicrobial activity of natural or artificial compounds, development and quantification of microbial biofilms; determination of adhesion to inert and cellular substrate of bacteria; determination of bacterial invasiveness at cellular level. Dr. Petruta Preda written 10 ISI papers, 1 book chapter, 1 Romanian patent, and participated in 12 national and international symposiums and conferences.
Viorica Coroiu
Viorica Coroiu is currently scientific researcher III at the National Institute for Research and Development for Biological Sciences, Bucharest, Romania. She has expertise in domains: cell biology of extracellular matrix in tissue remodeling, development of biomaterials for regenerative medicine, in vitro biocompatibility testing of biomaterials and medical devices. She designed and developed a cell culture laboratory with quality system implemented in according with European normative SR EN ISO 17025:2005 in the field of in vitro cytotoxicity evaluation of medical devices, biomaterials, plant components, nanostructured systems by MTT, MTS, RN and LDH assays, flow cytometry, light and fluorescence microscopy, in accordance with the requirements of the international standard SR EN ISO 10993-5:2009. Viorica Coroiu was Project Manajer of 3 projects, Project Responsible of 1 project and member in the research team of numerous national projects (over 26) and 1 international. She written 5 ISI papers, 4 Romanian patents, and participated at 6 national and international conferences.
Rodica Tatia
Rodica Tatia is scientific researcher in the Department of Cellular and Molecular Biology, from INCDSB Bucharest, graduate in Biology (2010), MA. in Medicinal and Cosmetics Chemistry, University of Bucharest (2012), PhD. student at the Faculty of Applied Chemistry and Materials Science at Polytechnic University of Bucharest. The experience acquired during 12 years in the Laboratory of Cell Cultures (accredited by RENAR according to ISO 17025:2005) at BCM Department, is specific of medical biotechnology field. The studies applied in performed research projects has consisted of in vitro testing experiments of various biomaterials and medical devices, applying cultivation techniques and maintenance of various cell lines like dermal fibroblasts, epithelial, osteoblastic and tumor. The activity consisted in applying of specific proliferation and cell viability evaluation methods, achieving of optical microscopy methods (specific stainings) and cell culture immunocytochemistry, performing of spectrophotometric methods to assess the proliferation and cell viability (MTT, RN). Studies have resulted in achievement as co-author of one patent and over 13 scientific articles published in scientific journals, and as co-author or author of over 8 scientific papers presented at national and international scientific conferences.
Cornelia Vasile
Prof. Dr. Cornelia VASILE from “Petru Poni” Institute of Macromolecular Chemistry, Institute of Excellence of the Romanian Academy, Romania. Prof. Dr. Cornelia Vasile is expert in physical chemistry of polymers, smart polymers, polymer blends and composites, environmentally degradable polymers, multicomponent polymeric systems characterization, polymer degradation. Her bibliography comprise of 600 scientific articles, 40 patents, and 4 books published in the last five years. She is IUPAC member - representative of Romanian Academy Chemical Section for Affiliate IUPAC member Programme for Young Researchers and member of the International Lignin Institute and Planetary Society.
Ecaterina Matei
Prof. Dr. Univ. Habil. Ecaterina MATEI iscurrentlyprofessor at the Ecometallurgy and Material Processing Department, Faculty of Material Science and Engineering from POLITEHNICA University of Bucharest. She has competences as laboratory manager, coordination of laboratory technical team in order to achieve specific activities: water, soil, wastes analyses, inter-laboratory comparisons, equipment maintenance. She written 5 books; 45 ISI papers, was responsible of 7 research projects.
Andra Mihaela Predescu
Dr. Andra Mihaela Predescu is lecturer and researcher at University POLITEHNICA of Bucharest, Romania, Faculty of Materials Science and Engineering. Dr. Predescu’s interest refers to modern methods and techniques for water decontamination and, more particularly, on production and characterization of advanced materials used for industrial wastewater treatment. Dr. Predescu has experience in working with spectrometric methods, such as X-Ray Fluorescence and X-Ray Diffraction. From 2012 she is researcher at Center for Research and Eco-Metallurgical Expertise from Politehnica University of Bucharest. Dr. Predescu has published over 45 papers, from which 29 ISI quoted and 8 books.
Monica-Elisabeta Maxim
Monica-Elisabeta Maxim is senior researcher at the “Ilie Murgulescu” Institute of Physical Chemistry, an Institute of Excellence of the Romanian Academy. She has expertise in the analysis and characterization of polymers, surfactants and their complexes by techniques like: UV-Vis spectroscopy, steady-state fluorescence, dynamic light scattering, FTIR, surface and interfacial tension, contact angle measurements and “layer-by-layer” deposition. The result of her studies is materialized in 14 scientific articles and she worked as a team member in 6 national projects and 2 inter-Academic Conventions and participated at 47 international and national conferences.