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ABSTRACT
Hydrogels nanoparticles of carbopol were prepared by free-radical polymerization technique. Methacrylic acid (MAA) imparted the pH-sensitive response to formulations. pH-sensitive behavior of the prepared formulations was evaluated by swelling index of the formulations at different pH 1.2 and 7.4 and it presented the maximum swelling index at pH 7.4. It was evident from the release behavior of drugs that maximum drug release was at higher pH 7.4, and less drug release at lower pH 1.2 that is acidic. Results of nanogels carrier systems are the indications of gastro-protective drug delivery of gastric irritant agent, ketoprofen.
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Notes on contributors
Rai Muhammad Sarfraz
Dr. Rai Muhammad Sarfraz has done his Ph.D. degree in Pharmaceutics from The Islamia University of Bahawalpur and he is serving as Assistant Professor Pharmaceutics at College of Pharmacy, University of Sargodha.
Muhammad Usman Khan
Muhammad Usman Khan is a Ph.D. Scholar in Pharmaceutics at College of Pharmacy, University of Sargodha.
Asif Mahmood
Dr. Asif Mahmood has done his Ph.D. degree in Pharmaceutics from The Islamia University of Bahawalpur, Pakistan and he is serving as Head of Department of Pharmaceutics and Associate Professor at Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
Muhammad Rouf Akram
Dr. Muhammad Rouf Akram has done his Ph.D. degree in Pharmaceutics from The Islamia University of Bahawalpur and he is serving as Assistant Professor Pharmaceutics at College of Pharmacy, University of Sargodha, Pakistan.
Muhammad Usman Minhas
Dr. Muhammad Usman Minhas has done his Ph.D. degree in Pharmaceutics from The Islamia University of Bahawalpur and he is serving as Associate Professor Pharmaceutics at College of Pharmacy, University of Sargodha, Pakistan.
Muhammad Naeem QAISAR
Muhammad Naeem QAISAR has done his Ph.D. degree in Pharmaceutical Chemistry from Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan and he is serving as Assistant Professor Pharmaceutical Chemistry at College of Pharmacy, University of Sargodha, Pakistan.
Muhammad Rizwan ALI
Muhammad Rizwan Ali are Ph.D. Scholars at College of Pharmacy, University of Sargodha, Pakistan.
Hasnain Ahmad
Hasnain Ahmad are Ph.D. Scholars at College of Pharmacy, University of Sargodha, Pakistan.
Muhammad Zaman
Dr. Muhammad Zaman has done his Ph.D. degree in Pharmaceutics from Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan and he is serving as Assistant Professor Pharmaceutics at Department of Pharmaceutics, University of Central Punjab, Lahore.