NIR-triggered drug delivery system based on Fe₃O₄-MoS₂ core-shell grafted poly(N-vinylcaprolactam): isotherm and kinetics studies

ABSTRACT

In this research, we report a low-cost and simple synthesis of a Fe₃O₄-MoS₂ core-shell grafted with poly (N-vinylcaprolactam) as a photothermal nanocarrier. The as-prepared nanocarrier exhibits a nanoscale size (70 nm), maximum adsorption capacity (q_max = 3.19 mg g⁻¹), and excellent photothermal characteristics. The release profile was investigated at different temperatures (37 and 50°C) and under NIR laser. The results revealed that 40%, 95% of curcumin were released within 5 h at 37 and 50°C, respectively. Furthermore, data obtained from release experiments under NIR laser reveal that 100% of curcumin was released within 10 min. Thus, the NIR triggered release studies indicate that this NIR-responsive nanocarrier enables increase drug release. The most effective parameters on adsorption were optimized and the maximum adsorption was achieved for contact time 2 min, pH 8, and temperature 37°C. The experimental data have been investigated using the Langmuir, Freundlich, Temkin, Dubinin-Radushkevich, and Redlich-Peterson isotherm models. The Langmuir model fits the experimental data dramatically better than the other isotherm models. Kinetics studies revealed that the adsorption followed a pseudo-second-order kinetic.

Graphical Abstract

KEYWORDS:

• Drug delivery
• magnetic nanoparticles
• MoS₂
• NIR laser
• thermo-sensitive polymer

Disclosure statement

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Notes on contributors

Homayon Ahmad Panahi

Homayoon Ahmad panahi Personal Information: Date of Birth: 1968. Educational Background Ph.D.  2003.  Science & Research Branch, Islamic Azad University, Tehran, Iran, Department of Mathematics. M.S.  1993. Sharif University, Tehran, Iran, College of Mathematics. B.S.  1990.  Arak University, Arak, Iran, Department of Mathematics. Areas of Expertise and Research InterestsHarmonic Analysis. Topological Group and Topological Semigroup. Fixed Point Theory. Banach Algebra.Academic ExperiencesVice Chancellor for Research, Islamic Azad University, Central Tehran Branch,  2011 (May 24) –Present, Vice Chancellor for Student Affairs, Islamic Azad University, Central Tehran Branch 2010-2011.Member of University Personnel Committee, 2008-Present.Iranian Mathematical Society Representative in the Department, 1998-Present.Chair of Department of Mathematics, Islamic Azad University, Central Tehran Branch 2005-2007.Member of University Research Board, Islamic Azad University, Central Tehran Branch, June 2008-NowUndergraduate & Graduate Advisor, 2005-2007.Chair of University Mathematics Competition Committee, 2008-Present.Chair of Department Mathematics Competition Committee, 2002-2003. Professional Memberships Director-in-Chief of Journal of Linear and Topological Algebra (http://jlta.iauctb.ac.ir)Ordinary member Iranian Math. Soc. Tehran, Iran 1996-present Iranian Mathematical Society Representative in the Department, 1998-Present.Membership in Editorial BoardsMember of the editorial board of Journal of Linear and Topological Algebra (http://jlta.iauctb.ac.ir)Courses TaughtHarmonic Analysis. Functional Analysis. Measure Theory. Operator Theory.Seminars on Harmonic Analysis Seminars on Banach Algebra. Mathematical Analysis I, II, and III. Topology.Analytic Geometry and Calculus I, II, and III.Algebra I, II.Complex Analysis.