Chitosan-PVA-co-poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Hybrid IPN-Nanogels for Transdermal Delivery of Ondansetron; Synthesis, Characterization and Toxicological Evaluation

ABSTRACT

Current study aimed to develop and evaluate interpenetrating polymer network (IPN) nanogels for transdermal delivery of ondansetron (OND) using combination of natural and synthetic polymers. Owing to their small size and biocompatible profile, nanogels have great potential as carriers for transdermal delivery that aids in penetration of drugs through layers of skin into blood stream. IPN nanogels were synthesized by free radical polymerization technique. Effective response for swelling and drug release were quantified at pH 5.5 and 7.4 simulating skin and blood. Overall results were satisfactory concluding that prepared IPN-nanogels were stable with excellent drug permeation profile across skin.

KEYWORDS:

• Nanogels
• ondansetron
• chitosan
• poly vinyl alcohol
• transdermal delivery

Disclosure

Authors declare that they have no conflict of interest.

Additional information

Funding

This project was funded by Higher Education Commission (HEC) of Pakistan and The Islamia University of Bahawalpur.

Notes on contributors

Sana Tanveer

Sana Tanveer, Principle researcher of the project at The Islamia University of Bahawalpur, Pakistan and Pharmacist/Analyst at Drug Testing Laboratory, Bahawalpur, Pakistan.

Mahmood Ahmad

Mahmood Ahmad, Professor of Pharmaceutics, Ex-Dean and Supervisor of the project at The Islamia University of Bahawalpur, Pakistan.

Muhammad Usman Minhas

Muhammad Usman Minhas, Co-supervisor and Associate professor of Pharmaceutics at University of Sargodha, Pakistan.

Aousaf Ahmad

Aousaf Ahmad, Co-researcher and assistant professor of Pharmaceutics.

Kifayat Ullah Khan

Kifayat Ullah Khan, Co-researcher and assistant professor of Pharmaceutics.