Synthesis and characterization of double molecular imprinted nanoparticles and investigation to adsorption of respiratory drugs

ABSTRACT

In this study, novel double molecular imprinted nanoparticles (DMIP nanoparticles) with multi-functional monomers were prepared for adsorption of salmeterol xinafoate (SAM) and fluticasone propionate (FLU) drugs. For this purpose, SAM and FLU imprinted poly (2-hydroxyethyl methacrylate-N-methacryloyl-(L)-alanine-N-methacryloyl-(L)-histidine) [p(HEMA-MAAL-MAH)] nanoparticles were synthesized by surfactant-free emulsion polymerization method. After the characterization, adsorption conditions were optimized, and the adsorption kinetics parameters were also calculated. In the selectivity experiments, budesonide (BS) and formoterol fumarate (FF) drugs were used as competitive drugs. These novel development DMIP nanoparticles have the potential for use in many different areas, for purposes such as drug release, separation, and purification.

KEYWORDS:

• Double molecular imprinted nanoparticles
• salmeterol xinafoate
• fluticasone propionate
• adsorption study

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This study was supported by Aliye Uster Foundation of Ege University and The Scientific and Technological Research Council of Turkey (TUBITAK), 2211/C National PhD Scholarship Program in the Priority Fields in Science and Technology.

Notes on contributors

Esra Feyzioğlu Demir

Esra Feyzioğlu Demir graduated from Ege University, Faculty of Science, Department of Biochemistry with a bachelor’s degree in 2011. In addition, she completed her master’s degree in 2013 and the Ph.D. degree in 2019 at Ege University Graduate School of Natural and Applied Science, Department of Biotechnology. Dr.Feyzioğlu Demir started her academic career as a lecture in Izmir University of Economics, Vocational School of Health Services, Department of Medical Laboratory Techniques in 2016. She has still worked in the same department as Asst. Prof. The research interests of Dr. Feyzioğlu Demir comprises biochemistry, biotechnology, molecular imprinting, polymeric materials, adsorption, separation and purification, affinity technics, drug release.

Sinan Akgöl

Sinan Akgöl graduted from Cumhuriyet University, Faculty of Science, Department of Chemistry with bachelor’s degree in 1993 and master’s degree in 1996. He completed Ph.D. degree in 2003 at Haccettepe University, Faculty of Science, and Department of Chemistry. He has worked as Professor in Ege University, Faculty of Science, and Department of Biochemistry since 2013. Dr. Akgöl established Biochemistry Research Group (BIOREGE) in 2010. Groups’ researches are heavily on development of specific adsorbents for purification of biomolecules from their natural environments. Research areas of Dr. Akgöl are chemical engineering and technology, biotechnology, bioprocess separation processes, enzyme engineering, chemical technologies, polymer technology, chemistry, biochemistry, natural sciences, engineering, and technology.