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Research Article

In-vitro cytotoxicity assessment and cell adhesion study of functionalized nTiO2 reinforced PEEK biocompatible polymer composite

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Pages 566-576 | Received 06 Jul 2021, Accepted 02 Nov 2021, Published online: 09 Dec 2021
 

ABSTRACT

This research aims to develop a nontoxic PEEK-based acrylic acid-functionalized nTiO2 reinforced polymer nanocomposite fabricated by injection molding. Functional groups in PEEK, synthesized nTiO2, and PEEK+nTiO2 composite have been identified through FTIR analysis. Effect of acrylic acid-functionalized nTiO2 particles on the thermal degradation was investigated using DSC, TGA analysis, and biocompatibility of PEEK+nTiO2 using in-vitro studies. The cytotoxicity level as 2.7% (grade 1, slight toxic level) and cell viability as 97.3% were identified in the direct method of cytotoxicity assessment. The indirect cytotoxicity method revealed slight toxic level. Excellent cell growth was identified through cell adhesion study using SEM analysis.

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Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors have no funding to report.

Notes on contributors

Mugilan Thanigachalam

Mugilan Thanigachalam doing full time research in the field of developing biopolymeric nanocomposites. His research interest includes bio composites, material science and machining. He has received master’s degree in Engineering Design (2019) and bachelor’s degree in Mechanical Engineering (2017) from Anna University, Tamil Nadu, India.

Aezhisai Vallavi Muthusamy Subramanian

Dr. Aezhisai Vallavi Muthusamy Subramanium received her Ph.D (2017) in Machining of Composite Materials. She is a university rank holder in PG programme and recipient of “Young Engineer Award” from Institute of Engineers, India for the year 2017-18.she is currently an Assistant Professor at Government College of Technology, Coimbatore, Tamilnadu. Her areas of interest are Additive Manufacturing, Material Science and Composite Materials.

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