ABSTRACT
The current study was carried out to evaluate the effects of cartilage-decellularized extracellular matrix (ECM) on Poly (3-hydroxybutyrate) (PHB) electrospun scaffold for cartilage tissue engineering. In this study, PHB scaffolds with three different percentages of ECM (1%, 2%, and 3%) were fabricated. Mechanical, chemical, and physical properties of scaffolds along with their interactions with cells were assessed. Results showed that by adding of ECM to the scaffolds, the Physiomechanical properties of combined scaffolds were modified, compared to the pure PHB scaffold. In the other hand, the biological behavior was increased by increasing the ECM ratio to the PHB.
Graphical abstract
Acknowledgments
The authors hereby greatly appreciate the support given by Isfahan University of Medical Sciences (398763).
Disclosure statement
No potential conflict of interest was reported by the author(s).
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Funding
Notes on contributors
Mohsen Asghari-Vostakolaei
Mohsen Asghari Vostakolaei graduated MSc of Anatomical sciences at the Isfahan University of medical sciences, Iran. Currently he is a PhD student at the aforementioned university. His research interest is on the differentiation of mesenchymal stem cells for tissue engineering applications.
Hamid Bahramian
Hamid Bahramian Renani received his PhD in Anatomical sciences from Isfahan University of medical sciences. He is associate professor of Anatomical Sciences in department of Anatomical Sciences, Isfahan University of Medical Sciences. He has acquired expertise in stem cells for cartilage and nervous tissue engineering.
Saeed Karbasi
Saeed Karbasi received his BSc degree in Material Engineering from Shiraz University, Iran, in 1994 and MSc and PhD degrees in Biomedical Engineering from Amirkabir University, Iran, in 1997 and 2005, respectively. He is currently full professor at Isfahan University of Medical Sciences, Iran. His research interests are including biomaterials, tissue engineering, and nanobiocomposites.
Mohsen Setayeshmehr
Mohsen Setayeshmehr obtained his MSc in the Applied Polymer Chemistry from Isfahan University, Isfahan, Iran. He graduated PhD in tissue engineering and regenerative medicine at Iran University of Medical Sciences, Tehran, Iran and currently he is assistant professor at Isfahan University of Medical Sciences, Iran. He is focusing on bioactive scaffolds and stem cells from alternative sources.