Molecularly Imprinted Polymers as Bioreceptors in Electrochemical Biosensor (ECBS) for Cholesterol Detection

ABSTRACT

Average Cholesterol level in an individual keeps increasing with years. The need for clinical assessment of bad cholesterol level rises as a consequence of increasing victims in coronary artery disease (CAD). Clinical diagnosis of cholesterol is time consuming, and there is a need for commercial solution of this analysis problem. Sensor technology, which caused a revolutionary change in the field of biotechnology, is widely used in many bioanalyte detection. Developing a biosensor for cholesterol detection is being attempted utilizing plenty of routes. Biosensor can be classified based on the type of analyte recognition (bioreception) and transducers. One such promising bioreceptor is molecularly imprinted polymers as it is reliable, as well as cost and time saving. Working of a biosensor can depend on the type of bioreceptors and the type of transducer coupled to it. Electrochemical transducer is mostly deployed in cholesterol sensor for better sensitivity. Electrochemical MIPs make use of polymers with good electrical properties, and further their sensitivity can be enhanced with other modifications. This revolutionary concept is having great scope for commercialization.

GRAPHICAL ABSTRACT

KEYWORDS:

• Biosensors
• Cholesterol
• Conducting polymers
• Electrochemical sensors
• Molecularly Imprinted Polymers

Acknowledgments

The authors acknowledge the funding received from the Department of Biotechnology, Govt. of India (Sanction No.: 102/IFD/SAN/770/2021-2022) to support this study.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The work was supported by the Department of Biotechnology, Ministry of Science and Technology, Govt.of India.

Notes on contributors

Kowsika Murugesan

Ms. Kowsika Murugesan is currently working as a Junior Research Fellow under DBT sponsored project at Central Institute of Petrochemicals Engineering & Technology: School for Advanced Research in Petrochemicals-Advanced Polymer Design and Development Research Laboratory (CIPET: SARP-APDDRL), Bengaluru. She has done her Bachelor’s degree in Plastics technology from CIPET. Previously she has worked as an Assistant Manager at Gujarat Fluorochemicals Research Centre (GFRC) in Gujarat Fluorochemicals Limited (GFL) with 02 years of Industrial research experience. Her current research interests are in the field of Polymer Nanocomposites, Polymer Characterization, Sensors, Electrochemical Biosensors.

Sonalee Das

Dr. Sonalee Das is presently working as a Jr. Scientist at Central Institute of Petrochemicals Engineering & Technology: School for Advanced Research in Petrochemicals-Advanced Polymer Design and Development Research Laboratory (CIPET: SARP-APDDRL), Bengaluru, one of the R&D wings of CIPET. She has 06 years of research experience in the field of Polymer Synthesis, Polymer Coatings & Adhesives, Biopolymers and its Nanocomposites. She has published 12 research papers and 05 book chapters.

Kingshuk Dutta

Dr. Kingshuk Dutta is currently employed as a Scientist at CIPET, India. Prior to this appointment, he had worked as an Indo-U.S. Postdoctoral Fellow at Cornell University (U.S.A.) and as a National Postdoctoral Fellow at IIT – Kharagpur (India), both funded by DST-SERB, GOI. Earlier, as a Senior Research Fellow funded by CSIR, GOI, he had carried out his doctoral study at University of Calcutta (India). He has been a recipient of the prestigious GATE and National Scholarship, both from MHRD, GOI; and was also awarded the Dr. D. S. Kothari Postdoctoral Fellowship by UGC, GOI. His areas of research interest lie in the fields of electrochemical, bioelectrochemical and photoelectrochemical devices, water treatment and biopolymers. Until date, he has contributed to 64 experimental and review papers in reputed international platforms, 30 book chapters and many national and international presentations. In addition, he has edited/co-edited 7 books published by Elsevier, the American Chemical Society and Wiley. He is a life member and an elected fellow of the Indian Chemical Society (India), the International Society for Development & Sustainability (Japan), and the Scholars Academic & Scientific Society (India). He is also the recipient of the Vivekananda Prize from Institute of Researchers (India).