ABSTRACT
The study aimed to develop, characterize, and evaluate matrix-type oral bi-layered mucoadhesive hydrogel membrane patches for the intestinal delivery of gliclazide. Surface pH, drug content, thickness, folding endurance, moisture content, water vapor transmission rate, and swellability of hydrogel membrane patches were found satisfactory. These patches were characterized by SEM, DSC, and FT-IR spectroscopy. In-vitro gliclazide release from these hydrogel membrane patches was sustained over 8 h. Ex-vivo study demonstrated good mucoadhesion of these hydrogel membrane patches. Therefore, these matrix-type oral bi-layered mucoadhesive-natured PNIPAM-co-MM/chitosan made-hydrogel membrane patches for intestinal delivery of gliclazide can be effectively used in type-II diabetes mellitus management.
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Additional information
Notes on contributors
Suma Oommen Sen
Dr. Suma Oommen Sen has more than 22 years of experiences in Pharmaceutical industries, teaching and research in the field of pharmaceutics. She has published several research articles, review articles and book chapters in reputed journals and books. She has worked on drug delivery system and novel drug delivery system. She has guided several M. Pharm. students.
Amit Kumar Nayak
Dr. Amit Kumar Nayak has over 14 years of research experiences in the field of pharmaceutics, especially in the development and characterization of novel biopolymeric and nanostructured drug delivery systems. Till date, he has authored more than 150 research and review publications in various high-impact peer-reviewed journals and 135 book chapters. He has edited/authored 34 international books to his credit. He has guided several PhD Scholars and M. Pharm Students. He has received University Foundation Day Research Award, 2019 and 2022 by Biju Patnaik University of Technology, Odisha.
Pritesh Devbhuti
Dr. Pritesh Devbhuti has over 21 years of experiences in teaching and research in the field of pharmaceutical chemistry. He has published more than 30 review and research papers in reputed journals. He has participated in several national and international seminars. He has guided several PhD Scholars and M. Pharm students. His research interests are Drug-lipid interaction, Modification of different natural polysaccharides and Synthetic Chemistry.
Kalyan Kumar Sen
Dr. Kalyan Kumar Sen has over 38 years of experiences in Pharmaceutical industries, teaching and research in the field of pharmaceutics. He has co-edited 5 books. He has published more than 100 review and research papers in reputed journals. He has guided several PhD Scholars and M. Pharm Students. He has also worked as reviewer in several reputed journals.