Polyphenols: A first evidence in the synergism and bioactivities

ABSTRACT

Polyphenols are natural compounds and the most plentiful with synergistic properties contributing to potential health benefits. This review describes the synergistic interactions of polyphenolic compounds; as yet, no literature review has been undertaken to consider the experimental evidence of synergistic effects of polyphenols. The polyphenolic compounds claimed to have synergistic activities are highly effective against oxidation, peptic ulcers, myocardial infarction, tumors, and a variety of other conditions. In addition, anticancer activity via apoptosis and antibacterial, antifungal, anti-inflammatory, and estrogenic behaviors have also been reported. Apart from the synergistic effects of polyphenols, this review also illustrates their specific health benefits too and bioavailability in humans. The toxicity of some polyphenolic agents, including antinutritional effects, chronic nephrotoxicity, reduction in net protein utilization and antiluteinizing hormone, and tumor development, is also evaluated. Synergistic treatment approaches may be effective in the treatment of many diseases. These findings provide information about the benefits of polyphenol compounds in combination, which could be useful for future studies.

KEYWORDS:

• Synergistic effects
• polyphenols
• pharmacological activities
• antioxidant
• human health

Authors Contributions

Saikat Mitra: Conceptualization, Formal analysis, Investigation, Writing - Original draft, Abu Montakim Tareq: Conceptualization, Formal analysis, Editing, Visualization, Rajib Das: Formal analysis, Resources, Editing, Talha Bin Emran: Resources, Conceptualization, Formal analysis, Writing – Review & Editing, Visualization, Supervision, Project administration, Firzan Nainu: Formal analysis, Writing - Review & Editing, Arka Jyoti Chakraborty: Formal analysis, Investigation, Islamudin Ahmad: Investigation, Discussions, Trina E. Tallei: Formal analysis, Writing – Review & Editing, Abubakr M. Idris: Formal analysis, Writing – Review & Editing, Jesus Simal-Gandara: Resources, Conceptualization, Formal analysis, Writing - Review & Editing, Visualization, Supervision.

Acknowledgments

The authors express their gratitude to Research Center of Advanced Materials, King Khalid University, Saudi Arabia, for support (award number RCAMS/KKU/G001/21).

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The authors express their gratitude to Research Center of Advanced Materials, King Khalid University, Saudi Arabia, for support (award number RCAMS/KKU/G001/21).