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Abstract
We explored the associations between early life experience, endocrine regulation, psychological health, and hippocampal integrity in 37 elderly volunteers. Specifically, a neurodevelopmental and psychological mediation model was tested: Retrospective early life parental care was hypothesized to influence hippocampal integrity and the development of self-esteem. In turn, hippocampal volume (via modulation of hypothalamic-pituitary-adrenal axis negative feedback) and self-esteem (via modulation of stress vulnerability) were suggested to influence the cortisol stress response. Results supported the two-mediator model. We propose that early life parental care impacts on an individual's developing brain and personality, which consequently contribute to the shaping of neuroendocrine stress responsivity.
Notes
This research was supported by a grant from the German Research Foundation (DFG) to VE, and by grants from the Canadian Institutes of Health Research (CIHR #81143), and the Natural Sciences and Engineering Research Council of Canada (#249996) to JCP. JCP holds a CIHR New Investigator Award. KD is a recipient of a CIHR doctoral award.