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Developmental Neuropsychology Volume 39, 2014 - Issue 3
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Original Articles

Neurodevelopmental Outcomes in Infants and Children With Single-Suture Craniosynostosis: A Systematic Review

Sarah J. KnightClinical Sciences, Murdoch Childrens Research Institute, Melbourne, Australia;Department of Paediatrics, The University of Melbourne, Melbourne, Australia;Psychological Sciences, The University of Melbourne, Melbourne, Australia;Victorian Paediatric Rehabilitation Service, Monash Children’s, Melbourne, AustraliaCorrespondence[email protected]
,
Vicki A. AndersonClinical Sciences, Murdoch Childrens Research Institute, Melbourne, Australia;Psychological Sciences, The University of Melbourne, Melbourne, Australia;Victorian Paediatric Rehabilitation Service, Monash Children’s, Melbourne, Australia;Psychology Department, The Royal Children’s Hospital, Melbourne, Australia
,
Megan M. Spencer-SmithClinical Sciences, Murdoch Childrens Research Institute, Melbourne, Australia;Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
&
Annette C. Da CostaClinical Sciences, Murdoch Childrens Research Institute, Melbourne, Australia;Psychological Sciences, The University of Melbourne, Melbourne, Australia;Department of Plastic and Maxillofacial Surgery, The Royal Children’s Hospital, Melbourne, Australia
Pages 159-186 | Published online: 17 Apr 2014
 
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Abstract

Children with single-suture craniosynostosis (SSC) are increasingly considered to be at high risk of adverse neurodevelopmental outcomes. This systematic review aimed to synthesise and critically appraise the existing literature on the neurodevelopmental features of SSC, with particular attention to methodological quality. A total of 33 articles based on 27 cohorts met inclusion criteria. In the context of variable methodological design and quality, most neurodevelopmental studies indicated that children with SSC are at increased risk for difficulties in cognitive, language, and motor domains during infancy (both pre- and post-surgery) and childhood. Limited information exists on factors influencing outcome.

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