Oscillatory Dynamics of Feedback Processing in Adolescents with Prenatal Cocaine Exposure

ABSTRACT

Prenatal cocaine exposure (PCE) has ramifications for feedback processing. Measuring neural oscillatory dynamics (during electroencephalography) provides insight into the time signatures and neural processes of feedback processing in adolescents with PCE. We measured spectral power in alpha and theta frequency bands while 49 adolescents with PCE and 34 non-drug exposed (NDE) performed a task with win/no-win feedback. Compared to NDE individuals, those with PCE showed reduced alpha power and increased theta power in response to no-win feedback. These findings suggest altered reactivity in PCE adolescents.

Conflicts of interest

The authors report no conflict of interest with respect to the content of this manuscript.

Dr. Potenza has consulted for and advised Shire, Rivermend Health, Opiant/Lightlake Therapeutics and Jazz Pharmaceuticals; received research support (to Yale) from the Mohegan Sun Casino and the National Center for Responsible Gaming; participated in surveys, mailings, or telephone consultations related to drug addiction, impulse control disorders or other health topics; consulted for and/or advised legal and gambling entities on issues related to impulse control and addiction; provided clinical care in the Connecticut Department of Mental Health and Addiction Services Problem Gambling Services Program; performed grant reviews for the National Institutes of Health and other agencies; has guest-edited journal sections; given academic lectures in grand rounds, CME events and other clinical/scientific venues; and generated books or chapters for publishers of mental health texts. The other authors report no financial relationships with commercial interests.

Contributors

Dr. Morie wrote the first draft of the paper and worked with co-authors on subsequent drafts. All authors contributed to the editorial process and have approved the final submitted version of the manuscript.

Additional information

Funding

Funding for this work included National Institute of Health grants K01DA042937, K01 DA034125 (MJC), T32 MH018268 (MJC), P50 DA09241, UL1-DE19586, RL1 AA017539, R01 DA006025, R01 DA017863, K05 DA020091; T32 DA007238 and R21 DA030665. KPM receives support from MH018268-31 and from K01DA042937. MNP was supported by R01 DA035058, R01 DA039136, the National Center for Responsible Gaming, the Connecticut Council on Problem Gambling, and the Connecticut Department of Mental Health and Addiction Services. Beyond funding, the funding agencies had no further role in the writing of the report or in the decision to submit the paper for publication.