USE OF DIFFERENTIAL SCANNING CALORIMETRY TO STUDY THE REPLACEMENT OF A GUEST MOLECULE FROM CYCLODEXTRIN–GUEST INCLUSION COMPLEXES

Abstract

Beta cyclodextrin is well known for its ability to form inclusion complexes with a wide class of compounds. The stability of the inclusion complex is largely governed by the hydrophobic nature of the included molecule. The included molecule can be replaced by a relatively more hydrophobic molecule. For studying such replacement reaction, isolation of the complex is often needed. A simple differential scanning calorimetric (DSC) method is proposed here to study such reaction without the isolation of the complex. DSC provides the melting points of the compounds, and from the variation of the melting points the nature of the included molecule can be obtained. The method is simple, sensitive, and relatively rapid.

Keywords:

• DSC
• Cyclodextrin

Acknowledgments