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Analytical Letters Volume 34, 2001 - Issue 15
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Original Articles

SIMULTANEOUS DETERMINATION OF RUTIN AND BENZOCAINE IN SUPPOSITORIES BY REVERSED-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY

J. Joseph-Charles Université Victor Segalen Bordeaux 2, UFR des Sciences Pharmaceutiques, Laboratoire de Chimie Analytique, 3 Ter Place de la Victoire, Bordeaux, Cedex, F-33076, FranceCorrespondence[email protected]
,
M. Montagut Université Victor Segalen Bordeaux 2, UFR des Sciences Pharmaceutiques, Laboratoire de Chimie Analytique, 3 Ter Place de la Victoire, Bordeaux, Cedex, F-33076, France
,
M.-H. Langlois Université Victor Segalen Bordeaux 2, UFR des Sciences Pharmaceutiques, Laboratoire de Chimie Analytique, 3 Ter Place de la Victoire, Bordeaux, Cedex, F-33076, France
,
C. Boyer Université Victor Segalen Bordeaux 2, UFR des Sciences Pharmaceutiques, Laboratoire de Chimie Analytique, 3 Ter Place de la Victoire, Bordeaux, Cedex, F-33076, France
&
J.-P. Dubost Université Victor Segalen Bordeaux 2, UFR des Sciences Pharmaceutiques, Laboratoire de Chimie Analytique, 3 Ter Place de la Victoire, Bordeaux, Cedex, F-33076, France
Pages 2685-2692 | Received 07 Mar 2001, Accepted 25 Jul 2001, Published online: 02 Feb 2007
 
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Abstract

A simple and precise reversed-phase HPLC procedure for the simultaneous determination of rutin and benzocaine in suppositories is proposed. The chromatographic conditions were: Apex ODS column; methanol-10 mM triethylamine aqueous solution pH 3.0 (57 : 43, v/v) as the mobile phase; detection wavelength, 270 nm. Calibration curves were linear at concentration ranges 6.0 μg ml−1–14.0 μg ml−1 and 1.5 μg ml−1– 3.5 μg ml−1 for rutin and benzocaine, respectively. The reproductibility was 1.05% and 0.95% for rutin and benzocaine, respectively.

ACKNOWLEDGMENTS

Charles-H. Guilloteau is gratefully acknowledged for his technical assistance.

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