DIFFERENTIAL PULSE VOLTAMMETRY FOR DETERMINATION OF PARACETAMOL AT A PUMICE MIXED CARBON PASTE ELECTRODE

Abstract

A method for determination of paracetamol is established by the differential pulse voltammetry (DPV) using a pumice mixed carbon paste electrode with the pumice weight percent of 6% (m/m) in 0.1 mol l⁻¹ H₂SO₄. The anodic peak potential is ca. 0.640 V (vs. SCE). There is a good linear relationship between the peak current and paracetamol concentration in the range of 6.0 × 10⁻⁸ – 1.0 × 10⁻⁶ mol l⁻¹, and 2.0 × 10⁻⁶ – 9.8 × 10⁻⁵ mol l⁻¹ with the detection limit of 2.0 × 10⁻⁸ mol l⁻¹. Compared with the carbon paste electrode, the detection limit of this method decreases two orders of magnitude. This method is rapid, simple, accurate and highly sensitive. Satisfactory results for determination of paracetamol in pharmaceutical preparations and urine are obtained.

Keywords:

• Paracetamol
• Pumice
• Carbon paste electrode
• Differential pulse voltammetry
• Adsorption

Acknowledgments