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Original Articles

SPECTROPHOTOMETRIC DETERMINATION OF SOME ANTIDEPRESSANT DRUGS

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Pages 1163-1170 | Received 30 Oct 2001, Accepted 13 Mar 2002, Published online: 25 Oct 2011
 

ABSTRACT

Amitriptyline and desipramine hydrochlorides react with niobium (V) thiocyanate complex forming yellow ion-association compounds. These compounds are insoluble in water, but fairly soluble in organic solvents. The formation and extraction conditions of the compounds have been established, and a new spectrophotometric method has been developed for the determination of amitriptyline and desipramine in the concentration range of 1–12 µg/mL and 1–6 µg/mL, respectively.

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