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Original Articles

QUANTITATIVE DETERMINATION OF FLUCONAZOLE IN SYRUPS BY FIRST ORDER DERIVATIVE SPECTROPHOTOMETRY

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Pages 1193-1204 | Received 27 Jan 2002, Accepted 15 Mar 2002, Published online: 25 Oct 2011
 

ABSTRACT

An improved first order derivative spectrophotometric method was applied for the determination of fluconazole in syrups. The spectral interference observed in syrups was eliminated by using first derivative method. Distilled water is used as a solvent throughout the study. The chosen wavelength was 271.6 nm at first order derivative spectrum and the linear concentration range was 126.0–462.0 µg mL−1. Recovery studies shows the method is accurate and precise with 102.2% mean recovery value and 1.78 coefficient variation. Detection limit was found to be 4.53 µg mL−1.

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