ABSTRACT
A chemiluminescence (CL) system for metoclopramide combined with a flow-injection system is presented in this paper. It is based on CL produced by the oxidation of metoclopramide by permanganate. It was found that formaldehyde could highly enhance the CL intensity. The method permits the determination of metoclopramide over a concentration range of 0.06–60 µg/mL with the detection limit (signal/noise) of 0.03 µg/mL. The relative standard deviation (RSD) for 2 µg/mL metoclopramide standard solution was 1.6% (n = 11). The method has been applied successfully to the determination of metoclopramide in tablets and injections.