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Analytical Letters Volume 35, 2002 - Issue 10
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Original Articles

STRUCTURE-PROPERTY RELATIONSHIPS OF THIOACRIDINES; THEIR ELECTROCHEMICAL OXIDATION AS A MODEL OF METABOLIC DEGRADATION

K. Nesmerak Departments of Analytical Chemistry, Charles University of Prague, Albertov 2030, 128 43 Prague 2, Czech RepublicCorrespondence[email protected]
,
I. Nemec Departments of Analytical Chemistry, Charles University of Prague, Albertov 2030, 128 43 Prague 2, Czech Republic
,
M. Sticha Organic Chemistry, Charles University of Prague, Albertov 2030, 128 43 Prague 2, Czech Republic
,
I. Nemcova Departments of Analytical Chemistry, Charles University of Prague, Albertov 2030, 128 43 Prague 2, Czech Republic
&
V. Horka Departments of Analytical Chemistry, Charles University of Prague, Albertov 2030, 128 43 Prague 2, Czech Republic
Pages 1617-1629 | Received 10 Apr 2002, Accepted 20 Apr 2002, Published online: 02 Feb 2007
 
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ABSTRACT

The relationships of structure vs. electrochemical and vs. chromatographical properties of thirteen 9-(alkylthio)acridines were studied and quantified by correlation equations between E 1/2 (t r , resp.), and substituent constants. The study of electrochemical oxidation of these compounds as the model of their possible metabolic degradation was performed. The oxidation products were separated and analysed by mass spectrometry. The probable scheme of electrochemical oxidation of studied derivatives was proposed.

ACKNOWLEDGMENTS

We are grateful to Prof. Jacques Barbe (Faculté de Pharmacie, Marseille) for the supplying with the studied compounds.

This work was supported by grants No. 241/1999 and 219/2000 from Grant Agency of Charles University of Prague, Research Project MSM 113 1000002 (Czech Republic), and Cost Action B 16.001.

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