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Analytical Letters Volume 36, 2003 - Issue 4
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CHROMATOGRAPHY

Determination of Methanol by 4-[N-Methyl, N-(1-naphthylmethyl)]-amino-4-oxo-butanoic Acid in Presence of 4-Dimethylaminopyridine and 1-Ethyl-3-(3-dimethylaminopropyl) Carbodiimide Hydrochloride as Catalysts

Chia-Chi Kuo Graduate Institute of Pharmaceutical Sciences and School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, P.R. China
,
Yen-Hsia Wen Graduate Institute of Pharmaceutical Sciences and School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, P.R. China
,
Shihn-Sheng Wu Graduate Institute of Pharmaceutical Sciences and School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, P.R. ChinaCorrespondenceM [email protected]
&
Hsin-Lung Wu Graduate Institute of Pharmaceutical Sciences and School of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan, P.R. China
Pages 813-825 | Received 07 Aug 2001, Accepted 18 Nov 2002, Published online: 02 Feb 2007
 
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Abstract

High performance liquid chromatography (HPLC) with chemically removable derivatizing reagents for the analysis of methanol has been developed. Methanol was derivatized with 4-[N-methyl, N-(1-naphthylmethyl)]-amino-4-oxo-butanoic acid (NAOB), using 4-dimethylaminopyridine (DMAP) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) as activators. NAOB and the activators are chemically removable and can be removed by aqueous base and acid treatment after derivatization to minimize reagent interference in chromatography. The method can simultaneously determine methanol, ethanol and 1-propanol. The proposed HPLC method was validated for linearity, specificity, accuracy and reproducibility. The method was applied to the analysis of methanol spiked in Ipecac fluid extract with a satisfactory recovery (>95%).

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