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Analytical Letters Volume 36, 2003 - Issue 8
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SENSORS

An Electrochemical Immunosensor for Assays of C-Reactive Protein

Jun-Jie Zhu Laboratory of Mesoscopic Materials Science, Department of Chemistry, Nanjing University, Nanjing, P.R. ChinaCorrespondence[email protected]
,
Jin-Zhong Xu Laboratory of Mesoscopic Materials Science, Department of Chemistry, Nanjing University, Nanjing, P.R. China
,
Jin-Tao He Laboratory of Mesoscopic Materials Science, Department of Chemistry, Nanjing University, Nanjing, P.R. China
,
Yi-Jun Wang Laboratory of Mesoscopic Materials Science, Department of Chemistry, Nanjing University, Nanjing, P.R. China
,
Qiang Miao Laboratory of Mesoscopic Materials Science, Department of Chemistry, Nanjing University, Nanjing, P.R. China
&
Hong-Yuan Chen Laboratory of Mesoscopic Materials Science, Department of Chemistry, Nanjing University, Nanjing, P.R. China
Pages 1547-1556 | Received 25 Feb 2003, Accepted 10 Mar 2003, Published online: 18 Aug 2006
 
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Abstract

An electrochemical immunosensor has been constructed by the self-assemble technique and studied by the AC impedance and potential method respectively. The change of the surface impedance shows that the antibody can be assembled on the electrode surface and recognize the antigen. The gold nanoparticles are not only used to immobilize the CRP antibody, but also can amplify the potential response. The immunosensor responds to antigen in the linear range from 5 to 25 µg/mL and can meet the needs of clinical assay.

Acknowledgment

This work is supported by the National Natural Science Foundation of China (No. 20275015, No. 90206037) and the Doctoral Foundation of Ministry of Education of China (20020284022).

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