Nano-Sized Copper Oxide Modified Carbon Paste Electrodes as an Amperometric Sensor for Amikacin

Abstract

A novel nano-sized copper oxide modified carbon paste electrode has been fabricated to determine the amikacin by cyclic voltammetry and amperometry. The oxidation current of the amikacin on nano-sized copper oxide modified carbon paste electrode was about 40 times higher than that on bulk CuO modified carbon paste electrode. The curve of i vs. concentration was linear in the range of 2–200 µM of the amikacin concentration with a correlation coefficient of 0.998. The detection limit was ca. 1 µM of amikacin with the signal to noise ratio of 3.

Keywords:

• Copper oxide nanoparticle
• Modified electrode
• Amperometric sensor
• Amikacin.

Acknowledgments

This work is supported by the National Natural Science Foundation of China (No. 20075010, No. 29835110, No. 50072006). Financial supports from the Science and Technology Foundation of Jiangsu Province of China (BG2001039) are also gratefully acknowledged.